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What is Low Dose Naltrexone (LDN)?

Imagine a medication originally developed to treat opioid and alcohol dependence, only to be rediscovered decades later for a completely different purpose: supporting the immune system, reducing inflammation, and relieving symptoms of chronic conditions. That’s the remarkable story of Low Dose Naltrexone (LDN).

LDN is simply naltrexone used in much smaller doses—typically between 0.5mg and 4.5mg, compared to the standard 50mg dose used for addiction. But in these tiny amounts, this medication takes on a completely different personality. Rather than blocking opioids long-term, it briefly “nudges” the body in a unique way that can trigger healing and restore balance. And that’s where things get interesting.

 

How Does LDN Work?

 

The Science Behind Its Benefits

While researchers continue to explore LDN’s full potential, its effects are linked to three key mechanisms:

Boosting Natural Endorphins


  • LDN temporarily blocks opioid receptors, prompting your brain to produce more endorphins—your body’s natural pain-relieving and mood-enhancing chemicals. This increase can help regulate the immune system, reduce chronic pain, and improve overall well-being.

Reducing Inflammation


  • LDN interacts with Toll-like Receptor 4 (TLR4), a key player in the immune system’s inflammatory response. In many chronic conditions, TLR4 is overactive, fueling persistent inflammation. LDN helps calm this response, which may provide relief for autoimmune and inflammatory disorders.

Calming Brain Immune Cells 

  • Microglia, the immune cells in your brain, can become overactive due to stress, injury, or chronic illness, contributing to fatigue, pain, and brain fog. LDN appears to soothe these cells, helping patients feel clearer, more energized, and focused.

 

 

What Conditions Can LDN Help With?

 

Though considered an “off-label” therapy, LDN is increasingly used by innovative healthcare providers to support a wide range of conditions, including:

 

Autoimmune Diseases  

  • Hashimoto’s thyroiditis  
  • Rheumatoid arthritis  
  • Lupus (SLE)  
  • Multiple sclerosis (MS)  
  • Inflammatory bowel diseases (Crohn’s, ulcerative colitis)

 

Chronic Pain Conditions  

  • Fibromyalgia  
  • Complex regional pain syndrome (CRPS)  
  • Chronic pelvic pain

 

Neurological & Mental Health Conditions  

  • Long COVID-related brain fog and fatigue  
  • Multiple sclerosis  
  • Anxiety and depression

 

Hormonal & Metabolic Conditions  

  • Endometriosis  
  • Polycystic ovary syndrome (PCOS)  
  • Hashimoto’s thyroiditis

 

Cancer Support  

  • Used under physician guidance to support quality of life and immune resilience during or after cancer treatment.

 

Important: LDN is not a cure, but for many patients, it’s a transformative tool that reduces symptoms, boosts energy, and enhances quality of life.

 

Why Choose Compounded LDN?

 

Standard pharmacies typically stock naltrexone in 50mg tablets, which is unsuitable for LDN’s low-dose requirements. That’s where compounding pharmacies shine.

At Custom Care Compounding Pharmacy, we prepare LDN tailored to your unique needs, ensuring the precise dose and form prescribed by your healthcare provider. Our customized options include:

  • Capsules: Free of fillers, allergens, or dyes for sensitive patients.  
  • Sublingual Tablets or Troches: Ideal for faster absorption or for those who have difficulty swallowing.  
  • Liquid Suspensions: Perfect for pediatric patients or those preferring a liquid format.

We collaborate closely with prescribers and patients to ensure your LDN therapy is personalized, effective, and convenient—because your health deserves a custom approach.

 

Why Trust Custom Care Compounding Pharmacy?

 

  • Expertise: Our pharmacists are highly trained in compounding LDN to meet exact specifications.  
  • Quality: We use only high-quality, FDA-approved ingredients to ensure safety and efficacy.  
  • Partnership: We work directly with your healthcare provider to optimize your treatment plan.  
  • Support: Have questions about LDN or your prescription? Our team is here to guide you every step of the way.

 

Frequently Asked Questions (FAQ)

 

Q: Is LDN FDA-approved?
A: Naltrexone is FDA-approved in 50mg doses for addiction treatment. LDN (0.5mg–4.5mg) is an “off-label” use, meaning it’s prescribed at a lower dose for other conditions based on clinical experience and emerging research. 

Q: How long does it take to feel results with LDN?
A: Typically, it will take about 6 weeks to feel results. Some people notice improvements within days or weeks, while others may need 2–3 months to experience full benefits. LDN often works gradually as it modulates the immune system and inflammation.

Q: Are there side effects?
A: LDN is typically well-tolerated. The most common side effect is vivid dreams, especially if taken at night. Other potential side effects include sleep disturbances, headaches, or temporary mood changes. Recent research suggests, these are signs that your dose might be slightly higher than what is ideal for you. Dosing back down slightly for a period before increasing the dose again usually resolves these symptoms.

Q: Can I take LDN with my current medications?
A: LDN is generally safe to use alongside most medications, but it should not be taken with opioid-containing drugs due to its receptor-blocking action. Always consult with your healthcare provider.

Q: Is LDN addictive?
A: No. LDN is not addictive and does not produce a “high.” In fact, it’s traditionally used to help treat addiction in high doses.

Q: How do I get started on LDN?
A: A prescription is required. We recommend speaking with your healthcare provider or contacting our pharmacy for a referral to a provider familiar with LDN therapy.

 

Why Choose Our Pharmacy for LDN?

 

At Custom Care Compounding Pharmacy, we specialize in personalized medications that support healing from the inside out. Our team compounds LDN with precision, ensuring quality, purity, and consistency. Whether you’re a patient exploring options or a prescriber looking for a trusted partner, we’re here to support you with:

  • Carefully selected ingredients
  • Multiple dosing options
  • Rapid turnaround times
  • Direct pharmacist consultations

 

Ready to Explore LDN?

If you’re curious about how LDN could support your health, talk to your healthcare provider to see if it’s right for you. Already have a prescription? Contact Custom Care Compounding Pharmacy today to discuss your custom LDN formulation. Let us help you take the next step toward feeling your best.

 

Call Us: 925.830.4631 

Fax: 925.830.0125

Email: Pharmacy@customcarecompounding.com 

*Email jclauser6422@gmail.com for more information or if you’re interested in a LDN seminar